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Product info: Antibiotics - Doxycycline
Doxycycline: Doxycycline (VIBRAMYCIN) is a tetracycline antibiotic. It works by preventing the growth and spread of bacteria. Antibiotics will not work for colds, flu, or other viral infections. It fights bacteria in the body, including pneumonia and other respiratory tract infections. Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, chlamydia, periodontitis (gum disease), and anthrax (after inhalational exposure) and others. Doxycycline may also be used for other purposes not listed in this medication guide.

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Doxycycline Hyclate
Dosage Form: capsules

Rev. 03/08

Rx Only

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Doxycycline Hyclate Capsules and other antibacterial drugs. Doxycycline Hyclate Capsules should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
Doxycycline Hyclate Description


Doxycycline Hyclate is a. broad-spectrurn antibiotic synthetically derived from oxytetracycline. The structural formula is as follows:

with a molecular formula of C22H24N2O8•H2O and a molecular weight of 462.46. The chemical designation for doxycycline is 4-(Dimethylamino)- 1,4,4a,5,5a,6,11,12a - octahydro - 3,5,10,12,12a - pentahydroxy - 6 - methyl - 1,11 - dioxo - 2 - naphthacenecarboxamide monohydrate. Doxycycline is a light yellow crystalline powder. Doxycycline Hyclate is soluble in water.

Doxycycline has a high degree of lipoid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. Doxycycline will not degrade into an epianhydro form.
Doxycycline Hyclate - Clinical Pharmacology

Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral administration.

Following a 200 mg dose, normal adult volunteers averaged peak serum levels of 2.6 mcg/mL of doxycycline at 2 hours decreasing to 1.45 mcg/mL at 24 hours. Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal function (creatinine clearance about 75 mL/min). This percentage excretion may fall as low as 1-5%/72 hours in individuals with severe renal insufficiency (creatinine clearance below 10 mL/min). Studies have shown no significant difference in serum half-life of doxycycline (range 18-22 hours) in individuals with normal and severely impaired renal function.

Hemodialysis does not alter serum half-life.

Results of animal studies indicate that tetracyclines cross the placenta and are found in fetal tissues.
 
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